App Store Guideline 1.4.3 explained: Regulated substances

Guideline 1.4.3 sits in Apple's Safety section and is most relevant to health, safety, and physical harm.

This page summarizes the review risk in practical terms and links to the official Apple source for the exact rule text.

Apple applies extra scrutiny to apps that could affect health, safety, diagnosis, treatment, or physical behavior.

Apple applies extra scrutiny to apps that could affect health, safety, diagnosis, treatment, or physical behavior.

Claims about measurements, medical outcomes, or safety-critical behavior need strong support.

Review notes should include documentation when the app depends on regulated or specialist functionality.

The app makes health or safety claims that are not supported in the submission.

Medical, dosage, emergency, or physical-risk features lack documentation or disclaimers.

Screenshots or descriptions imply diagnostic accuracy beyond what can be validated.

Add conservative disclaimers and remove unsupported claims.

Provide regulatory, institutional, or methodology documentation when relevant.

Explain safety limits clearly in metadata, onboarding, and reviewer notes.

If Apple cited Guideline 1.4.3, reply with the exact change you made and where the reviewer can verify it.

If you believe the app already complies, provide concise evidence, navigation steps, and any supporting documentation instead of a generic appeal.

Keep the tone factual and cooperative. Avoid promising approval or arguing beyond what the submitted build and metadata can prove.